Clinical Validation Reports

Validation Clinical Reports and Abstracts

This section is intended to provide you clinical reports for the INVOS Cerebral Oximeter.
We will update this section with abstracts and other Clinical Reports, as they become available.

A link to the document is provided when available. These links may take you to
another site such as PubMed.

Validation

Brawanski A, Faltermeier R, Rothoerl RD, Woertgen C. Comparison of near-infrared
spectroscopy and tissue PO2 time series in patients after severe head injury and aneurismal
subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2002 22:605-611. [Abstract] [PubMed]

Kim MB, Ward DS, Cartwright CR, Kolano J, Chlebowski S, Henson LC. Estimation of jugular
venous O2 saturation from cerebral oximetry or arterial O2 saturation during isocapnic hypoxia.
J Clin Monitoring & Computing 2000;16:191-199. [Abstract]

Hongo K, Kobayashi S, Okudera H, Hokama M, Nakagawa F. Noninvasive cerebral optical
spectroscopy: depth-resolved measurements of cerebral haemodynamics using indocyanine
green. Neurological Research 1995;17:89-93. [Abstract] [PubMed]

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J Cereb Blood Flow Metab. 2002 May;22(5):605-11.

Comparison of near-infrared spectroscopy and tissue p(O2) time series in
patients after severe head injury and aneurysmal subarachnoid
hemorrhage.

Brawanski A, Faltermeier R, Rothoerl RD, Woertgen C.

Monitoring of local oxygen pressure in brain white matter (tip(O2)) and of local
hemoglobin oxygen saturation (rS(O2)) with near-infrared spectroscopy (NIRS)
are increasingly employed techniques in neurosurgical intensive care units. Using
frequency-based mathematical methods, the authors sought to ascertain whether
both techniques contained similar information. Twelve patients treated in the
intensive care unit were included (subarachnoid hemorrhage, n = 3; traumatic
brain injury, n = 9). A tip(O2) probe and an NIRS sensor were positioned over the
frontal lobe with the most pathologic changes on initial computed tomography
scan. The authors calculated coherence of tip(O2) and rS(O2) ts overall density
distribution, its distribution per data set, and its time evolution. The authors
identified a band of significantly correlated frequencies (from 0 to 1.3 x 10(3) Hz)
in more than 90% of the data sets for coherence and overall density distribution.
Time evolution showed slow but marked changes of significant coherence. By
means of spectral analysis the authors show that tip(O2) and rS(O2)signals
contain similar information, albeit using completely different registration
methodologies.

PMID: 11973433 [PubMed - indexed for MEDLINE]

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Neurol Res. 1995 Apr;17(2):89-93.

Noninvasive cerebral optical spectroscopy: depth-resolved
measurements of cerebral haemodynamics using indocyanine green.

Hongo K, Kobayashi S, Okudera H, Hokama M, Nakagawa F.

Department of Neurosurgery, Shinshu University School of Medicine,
Matsumoto, Japan.

To investigate the feasibility of a newly developed, near-infrared optical
spectroscopy device, we analysed measurements of the infrared tracer
indocyanine green (ICG) using sensors with a single near infrared light source and
multiple light detectors. Two ml of ICG dye, 1.0 mg ml-1 in concentration, were
injected into the internal carotid artery during cerebral angiography in 14 adult
patients. The resultant washout curves were measured bilaterally using sensors
with 4 detectors spaced at 10, 20, 30 and 40 mm from the infrared light source on
the right side, and 15, 25, 35 and 45 mm from the source for the left side,
respectively. Washout curves were analysed to determine the relative amplitude
of the ICG absorption signal and deduce each detector's penetration distance.
When ICG was injected into the internal carotid artery, relative absorption
increased with detector distance from the light source. No substantial difference in
attenuation was observed in any of the detectors during external carotid injection
of ICG. The resultant information related depth of penetration of the light with
source-detector separation distances. The feasibility of the system for measuring
cerebral oxygen saturation and haemodynamics noninvasively or monitoring at
bedside is discussed.

PMID: 7609855 [PubMed - indexed for MEDLINE]

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